University of Hawaii ready to introduce Athletics Director Ben Jay

Ben Jay, the University of Hawaii's new athletics director, will be introduced to local media at a Thursday afternoon press conference.

Jay, who has served as senior associate athletics director at Ohio State University for the past six years, was named to the top post within UH's athletics department earlier this month.

He will be paid $293,000 annually during the initial three years of his contract, with opportunities for bonuses if certain goals are met, according to KITV. The local ABC affiliate said Jay will get an extra month's salary if the Warriors win the Mountain West Conference championship, and $7,500 if the football team makes it to a bowl game or the basketball team makes it to the NCAA tournament.

Jay is replacing Jim Donovan, who was reassigned to another post on the Manoa campus in the wake of the botched Stevie Wonder concert earlier this year. Donovan was recently named athletics director at Cal State Fullerton.

Source: http://feedproxy.google.com/~r/bizj_pacific/~3/55GMsBwIAOw/university-of-hawaii-ready-to.html

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Cancer cells co-opt immune response to escape destruction

Dec. 18, 2012 ? Researchers at the University of California, San Diego School of Medicine report that tumor cells use stress signals to subvert responding immune cells, exploiting them to actually boost conditions beneficial to cancer growth.

The findings are published in the December 18 online issue of the journal PLOS ONE.

Lead author Navin R. Mahadevan, a graduate student in the Laboratory of Immunology at the UC San Diego Moores Cancer Center, and colleagues found that tumor cells manipulate a fundamental cellular mechanism called unfolded protein response (UPR). In all cells, UPR is used to maintain homeostasis, or equilibrium, in the endoplasmic reticulum (ER) - the cell's protein-making factory. When, for a variety of reasons, a cell is subjected to overwork, ER stress occurs and a compensatory UPR is triggered.

"The goal is to understand how ER stress is transmitted and how this is amplified by receiver cells to attack vulnerable aspects of the immune system," said principal investigator Maurizio Zanetti, MD, who heads the Laboratory of Immunology and is director of Tumor Immunology at the Center for Immunity, Infection and Inflammation at UC San Diego.

"These findings suggest that the tumor UPR should be a target of therapy, not only for its intrinsic function in promoting tumor adaption and survival, but now for its external role in subverting the anti-tumor immune response."

When a UPR response is triggered, one of two things can happen. Either UPR restores homeostasis by slowing cellular processes and synthesizing chaperone molecules to ease the burden on the endoplasmic reticulum or it decides homeostasis can't be restored and the cell is better off dying. The latter is called apoptosis, or programmed cell death.

In research published last year, Zanetti and colleagues found that the UPR is transmissible: It can travel from one cell to another. In normal cells, ER stress is transient with the UPR usually restoring normal function. But cancer cells thrive in an environment in which low oxygen and scarce nutrients, such as glucose, induce continuous ER stress. For them, a sustained ER stress response "offers a survival advantage by promoting cancer cell adaptation, continued growth, and inflammation that is more damaging than healing," Zanetti said.

In the latest study, the scientists found that the transmissible ER stress response (TERS), which emanates from tumor cells experiencing ER stress, alters immune cells in such a way that they no longer function to help fight off cancer. Normally dendritic cells - the sentinels and information couriers of the immune system - train T cells (the immune system's enforcers) to specifically kill foreign entities. In the case of cancer, however, T cells are unable to properly eliminate tumor cells - confounding efforts to develop more effective cancer treatments. The new findings implicate TERS as cancer's siren call. It brainwashes dendritic cells so that they ineffectively communicate with T cells, reducing anti-tumor immunity while increasing tumor growth.

"This is one of the hot topics of contemporary immunology," said Mahadevan. "Our paper shows that TERS - and by inference ER stress in tumor cells - has the ability to negatively affect the sanctuary of the immune response."

Zanetti said the research further elucidates the fundamental processes that tumor cells use - or abuse - to manipulate their local microenvironment to promote their survival and growth. And it points to an area of drug development the pharmaceutical industry will likely focus on over the next decade.

Targeting the UPR, he said, may also help improve efficacy of long-sought cancer vaccines which have thus far been hampered by the ability of cancer cells to subvert the immune response, perhaps through mechanisms like TERS.

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Story Source:

The above story is reprinted from materials provided by University of California, San Diego Health Sciences, via Newswise.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Navin R. Mahadevan, Veronika Anufreichik, Jeffrey J. Rodvold, Kevin T. Chiu, Homero Sepulveda, Maurizio Zanetti. Cell-Extrinsic Effects of Tumor ER Stress Imprint Myeloid Dendritic Cells and Impair CD8 T Cell Priming. PLoS ONE, 2012; 7 (12): e51845 DOI: 10.1371/journal.pone.0051845

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/SBKA17-MO3E/121218203319.htm

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Senate Republicans aim to cut Sandy aid bill down to $24 billion

WASHINGTON (Reuters) - U.S. Senate Republicans sought to slash a $60.4 billion aid bill to cover reconstruction after Superstorm Sandy, proposing on Wednesday to fund only $23.8 billion in immediate disaster relief while assessing longer-term needs.

The far smaller initial amount is one of a number of Republican amendments aimed at cutting projects from a bill that they see as a "slush fund" loaded with questionable requests for spending on unrelated programs and big infrastructure.

Senator Daniel Coats of Indiana said his plan for $23.8 billion in initial funding would provide sufficient money for immediate needs through March 27, for work such as debris cleanup, repairing damaged equipment, rebuilding destroyed homes and businesses.

"It seems to me the most logical, responsible way to move forward is to identify the immediate needs and provide the immediate funding to meet those needs," said Coats, a member of the Senate Appropriations Committee.

He said longer-term needs could be considered next year, as Congress works on approving new money to keep government agencies and programs funded after a stopgap measure runs out on March 27.

Senate Democrats are trying to push through President Barack Obama's full $60.4 billion Sandy disaster aid request before the end of the year.

The Federal Emergency Management Agency's disaster relief fund had about $4.3 billion as of Tuesday, but the request for new funding has become tangled up with Congress' tense talks over the year-end "fiscal cliff" of automatic tax hikes and spending cuts.

"We don't have time right now to get all the way through and analyze the actual losses that were attributable to Sandy," said Republican senator James Inhofe of Oklahoma, adding that the full $60.4 billion looked like a "slush fund."

KATRINA FUNDS FLOWED SWIFTLY

Democrats argue that the full funding amount is needed to ensure that local businesses, municipalities and transit agencies in New York, New Jersey and Connecticut can launch full-fledged reconstruction projects immediately with the confidence that they will be fully reimbursed. Without the money approved, there will be delays, they say.

The move would mark a significant shift from Congress' actions following Hurricane Katrina in 2005, the last storm to wreak destruction on a similar scale as Sandy. Within two weeks after Katrina's storm surge flooded New Orleans and other Gulf Coast communities, Congress had appropriated $62.3 billion, and storm costs eventually topped $100 billion.

"When we had the devastation in New Orleans, we got the aid to those states very quickly," Senate Democratic leader Harry Reid said on the Senate floor, noting that far more people were affected by Sandy's path of destruction in a heavily populated area.

"We have to make a decision on this very, very important legislation before we leave here this week," Reid said. "I would hope that everyone would cooperate, but we have to do this."

The $23.8 billion offered in the Republican plan would be less than 30 percent of the initial $82 billion aid request made by New York, New Jersey and Connecticut earlier this month, based on early damage estimates from the October 29 storm.

The Republican plan would eliminate some $13 billion in infrastructure improvements aimed at helping to prevent damage from future storms. Among these are projects to keep New York City subway tunnels from flooding and to build sand barriers to protect some shorelines from storm surges.

It labels $5.4 billion to make transportation systems more resilient as "non-Sandy related." The Amtrak passenger rail agency, a frequent target of Republican budget-cutting efforts would get only $32 million under the bill, instead of $336 million.

Coats said such mitigation efforts were "long-term projects" that should not be immediately funded without further study.

The Republicans also aim to cut out $150 million for rebuilding fisheries, including those damaged by disasters in Alaska and the Gulf Coast. It would exclude a $58.9 million Department of Agriculture request to replant trees on private property due to "unsubstantiated" estimates for damage from Sandy.

The plan and other amendments to the Sandy aid measure are expected to be considered on Thursday and Friday.

Meanwhile, the Republican-controlled House of Representatives, which normally acts first on spending bills, is hanging back to see whether Senate Republicans are successful in cutting the request down to size.

Asked if he would also proceed with an amount below the $60.4 billion sought by Obama, House Appropriations Committee Chairman Hal Rogers, a Republican from Kentucky, said: "Let's see what the Senate does first."

(Reporting By David Lawder; editing by Christopher Wilson)

Source: http://news.yahoo.com/senate-republicans-aim-cut-sandy-aid-bill-down-021401916.html

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5 YouTube Videos to Help Winterize Your Home

(Reuters) - U.S. school districts have spent millions of dollars on metal detectors, security cameras and elaborate emergency-response plans since the 1999 massacre at Columbine High School, but almost nothing could have prevented Friday's massacre at a Connecticut elementary school, security experts say. A 20-year-old, heavily armed gunman opened fire Friday morning at Sandy Hook Elementary School in Newtown, Connecticut, killing 20 children and six adults before taking his own life, police said. ...

Source: http://news.yahoo.com/5-youtube-videos-help-winterize-home-165557666.html

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Geaux Teacher ? Homeschooling Tips That You Can Start Doing ...

The most common reason people choose to homeschool their children is deficiencies in the local public schools. But do not expect homeschooling to be simple and fun. Read this article to learn the elementary information required to successfully homeschool your children.

Write down the pros and cons of home schooling. Putting your reasons in writing may help it click in your mind, as well as help your spouse understand. Make understanding what you want to accomplish a priority, and be able to verbalize it when people ask about your decision to homeschool. That will make things simpler.

In order to better educate your child, compare the benefits and detriments of homeschooling versus public schooling. Construct a lesson plan from this list so that your kids will learn everything that public school couldn?t teach them. It?s a checklist of what to do and what not to do. Make sure you know where it is for future reference.

One of the major worries parents have about homeschooling is how to ensure their children get enough socialization time with other children. It is important that you provide your children with opportunities to make friends, for instance by finding some clubs or sport teams they can join. They can build social skills while having fun.

When you homeschool you can take advantage of things that children going to public school do not have the chance to do. One way to see how your child stands in comparison to public school students is to engage in standardized testing. If you feel they are falling behind, consider hiring a tutor.

Repeat key points and concepts for your child to soak them in. That?s why homeschooling parents assign spelling words, writing out definitions and note-taking. Such methods, including the use of rhymes, flashcards and songs can all foster great success.

Incorporate nature into your child?s education. They are educational for many reasons. Little kids can try collecting pretty and interesting leaves. Another teaching opportunity would be identifying different tree species and listing them in a notebook. Assign research of the species to older children and allow them to share with younger family members. Taking pictures helps ensure that you do not disturb the natural habitat of the species you are studying.

Before you consider homeschooling, make sure that you are qualified to be a teacher and understand what areas you may need help with. Be sure to also take into account your relationship, and address any issues that may impact their education.

Make sure you do plenty of research before deciding to homeschool your kids. There are many resources online to help make the right final decision for you and your family. Homeschooling is very exciting but you should not consider this option if you already have a full-time job or cannot afford to give your child a good education.

Make sure each child has plenty to do, and this can be challenging if they are at different ages. Make sure they have plenty of activities to participate in, and try to coordinate some with the themes of the work your school-age kids are doing. If your younger children are old enough, let them listen to a few lessons and take part in some activities as long as it does not get in the way of your homeschooling.

Having this article under your belt, you should now understanding that homeschooling really is within reach. If you use the advice you have been given in this article, there should be no issues with you homeschooling your children. Homeschooling allows your children to get a good education and will also help you get closer to your children.

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Source: http://www.geauxteacher.com/homeschooling-tips-that-you-can-start-doing-today-2/

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Jingle balls? Charity sells unusual ornaments

Courtesy Fallon

Scrotum-shaped Christmas baubles benefiting the London-based Orchid Cancer Society were created to raise awareness of testicular cancer.

By Ben Popken, TODAY contributor

Just in time for Christmas, a London-based charity that wants to?raise awareness of testicular cancer?is selling hand-crafted, shiny red ornaments ??in the shape of, well, balls.

The "Bauballs" were created by Matt Robinson and Tom Wrigglesworth of the London-based Fallon advertising agency, who?conceived of the idea while doing pro bono work for the U.K.-based?Orchid Cancer Charity, which is dedicated to fighting male cancers.?"Lots of men don't walk to talk about things like this unless you make it funny," Robinson today TODAY.com.

Similar products benefiting another?U.K. cancer charity,?Everyman, are for sale on Etsy?and have?names such as?"Santa's Sack" and "Baby, It's Cold Outside."?

The charity stunts bring to mind the annual "Movember" tradition, where men grow mustaches to also promote testicular cancer awareness.

Source: http://holidayblog.today.com/_news/2012/12/13/15885505-jingle-balls-cancer-charity-sells-unusual-christmas-ornaments?lite

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YotaPhone Android prototype with dual LCD and E Ink displays hands-on (video)

YotaPhone Android smartphone with dual LCD and E Ink displays  hands on video

Yesterday we brought you the announcement, and today we bring you the hands-on reality -- although bear in mind that this dual-screen YotaPhone is still very much a prototype. It certainly works -- pretty well, in fact -- but it's understandably rough around the edges and Yota Devices have plenty of work to do before the handset launches towards the end of next year. By way of a quick refresher: from the front this is a regular Android Jelly Bean phone with decent specs, including a 720 x 1,280 LCD display, dual-core 1.5GHz Snapdragon S4 processor, 2GB of RAM and a 12-megapixel main camera. Turn it around, however, and you reveal its double identity: a 200 dpi E Ink display which can hold a range of information -- calendar appointments, ebooks, tweets and whatever else you'd like -- without draining the battery. The good new is that the YotaPhone actually makes an even better first impression than we'd hoped, while the bad news is merely what's to be expected given the early stage of development. Click past the break for our hands-on video and impressions and all will become clear.

Continue reading YotaPhone Android prototype with dual LCD and E Ink displays hands-on (video)

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Source: http://www.engadget.com/2012/12/13/yotaphone-dualscreen-android-hands-on/

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The Laboratorium : If Code Is Law, Then Coders Are Lawyers

My latest review for Jotwell is up! It?s a review of Gabriella Coleman?s hot-off-the-presses new book, Coding Freedom: The Ethics and Aesthetics of Hacking. My review is titled If Code Is Law, Then Coders Are Lawyers and it praises Coleman?s perceptive, sympathetic account of how computer hackers have received, internalized, and challenged intellectual property law. A taste:

What makes Coding Freedom truly stand out, however, is that ?free software hacker? is an identity significantly constituted in relation to the law. To write free software is to choose to release one?s code using a carefully crafted copyright license; Coleman?s hackers elevate this legal issue to prime significance in their working lives. Coding Freedom is thus both the oft-told story of a legal idea?free software?and the lesser-known story of how numerous hackers, following personal but parallel tracks, have engaged with copyright law.

Coleman describes two crossing trajectories in copyright: the rise of an increasingly expansive domestic and international copyright system and the simultaneous rise of the free software movement, The former is bent on restricting uses; the latter on enabling them. The two collided in the early 2000s in the fights over the implementation of the DMCA, particularly the DeCSS case and the arrest of Dmitry Sklyarov. The result was the politicization of copyright in code: inspired by legal scholars and free software evangelists, many hackers saw themselves as participants in a struggle against a repressive copyright system.

Coding Freedom makes these familiar stories fresh. Free-software hackers were receptive to a fight-for-your-rights narrative precisely because they were already embedded in a professional context that foregrounded the political and ethical implications of copyright law. What is more, they engaged with copyright law as law, drafting licenses to achieve a free-software goals, endlessly debating the minutiae of license compliance, and critiquing copyright?s inconsistencies with the playful creativity of appellate litigators.

Source: http://laboratorium.net/archive/2012/12/12/if_code_is_law_then_coders_are_lawyers

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jkSOHU - DIY Home Improvement Source: How to Decorate Dining ...

Are you planning to throw a little party at home by inviting relatives??Do you want to bring something memorable without spending a huge cost??Maybe you could try to invite your relatives to dine together in your home.?This plan?needs some preparation, and decoration of the dining room and dining table.

Decorating your table for a special agenda can be a very exciting activity.?You can create as freely as possible with your dining table to bring something simple yet special.?Thinking about the concept is highly recommended to us better prepared for the things to be purchased or provided.?Great?concept, with the accordance of the theme and party purpose will be the right guidance for us to start designing.

Not only a good decoration, the food also has the strong influence ?also the food that we serve at the table as much as possible so inviting our show will not end up disappointing.?However, what are the things that must be prepared before inviting relatives for a meal at home??Here are the things that can be used as a guide to?decorating the dining room as well as your dining table to make it look better?.

Items needed:

- Eating utensils
- Candles?
- Tablecloths?
- Flowers?
- Marquetry plate?
- Napkins

The steps are:

1.?Choose a theme from the party or event in advance.?No need to pick a theme that complicated, just simple common theme.?Suppose theme of elegant, casual, romantic, or fancy.?In determining the theme, consider the purpose of the event as well as guests to invite.?Do not let the theme of the event confuse your guests.

2.?Clean up the candles, plates, spoons, forks, and other furniture in the dining room.?Clean up all the windows, tables, chair. Wipe it and do it at least 3 days before the big day and repeat if necessary. Make dining table the highest priority, so focus your attention on the area around the dining table.

3.?Determine the number of guests to invite.?It is very helpful to you in providing the number of seats in the dining room.?If this party is just a small party with guests less than 10 people, the regular dining table may be sufficient to accommodate your needs.?However, if the event covers a fairly large number of guests, of course you need a dining table and a number of additional seats to adjust the number of guests invited

4.?Choose a new table cloth, washed and ironed.?Clean tablecloth will make your guests feel comfortable eating at the table.?White colored, gold fringe or lace is perfect when combined with the color table made of dark wood.?If necessary, add a glass placemat for each guest, complete with a napkin or towel.

5.?Place a placemat adjusted by the number of seats on the dining table.?Adjust the distance is at least 2 inches between each placemat with other mats.?Placemat should have a width equal to the width of your seat at the dinner table.

6.?Put a decorative object in the middle of the dining table.?The object serves as a focal point to decorate your dining table so it can be in tune with the theme.?The item may be a pot of flowers, fruit baskets, candles, and so on.?If you want something romantic and luxurious, you can put some wax with a size 3 or 5 inches, and in combination with other decorations such as flowers or ribbons.

7.?Adjust the plates, bowls, knives, spoons and forks with the prone position.?You can see your cutlery set in accordance with the rules of table arrangement that we usually encounter while on the course table manner.There are 2 types of table arrangement, the European style or American style.?Both methods are different, but there are some important points that tend to be similar.

How to set Table Arrangement Under the Rule Table Manner

Place the fork on the left side of each plate while the spoon or knife in the right.?The position of cutlery must be vertical or perpendicular.?Glasses, cups, and bowls are placed on the right top of each placemat.?The glass is placed closest to the shortest and tallest coaster located somewhat farther to the right.?Lastly, fold and roll the napkin and place it at the top of placemat.?Your table is ready to be used for special events.

Once you are sure that the dining room and the dining table is ready and worthy to welcome guests, do not forget to serve something special as well.?Serve recipes that you do not have to be expensive and you also do not need to buy them out.?Simply serve something unique and out of your own creation or serve dishes with a special way so as not to seem too simple.?Regular meals are packed amazing to look attractive to enjoy on your special agenda.

Source: http://www.jksohu.com/2012/12/how-to-decorate-dining-room-for-special.html

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